Accufy Diagnostics

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Applications and Indications

The Accufy NGS tagging library preparation and Accufy NGS target enrichment technologies revolutionize the MRD analysis on liquid biopsy samples via NGS in that they features the greatest sensitivity, short sample prep time and preservation of both epigenetic and genetic information from the patient DNA molecules.  They can be coupled with existing NGS sample prep or target enrichment technologies.  They can also be used as a turnkey solution for multiomic NGS.  The potential applications of the technologies are many.

  1. MRD diagnosis and tracking via liquid biopsy;
  2. Gene fusion and chromosomal rearrangement detection and cancer screening;
  3. Multiomic NGS based disease studies.

For more details

Applications

Genetic Mutations

Insertion–deletion mutations (indels)

Non-small cell lung cancer

Example: EGFR exon 19 deletions 

Gene mutations

Colorectal cancer

Example: KRAS (absence of mutations in codons 12 and 13)

Exon alterations

Ovarian cancer

Example:BRCA1, BRCA2 alterations 


Gene Amplification and Gene Fusion

Gene amplification

Breast Cancer

Example: (HER2) amplification

Gene fusions

Cholangiocarcinoma

Example:FGFR2 fusions  

Gene fusions

Solid tumors

Example:NTRK1/2/3 fusions 


Epigenetic Alterations

Promotor Hypermethylation

Colorectal cancer

Example: NDRG4 (N-myc downstream-regulated gene 4) 

Promotor Hypermethylation

Colorectal cancer

Example: BMP3 (bone morphogenetic protein 3) 

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